RESPONSE: Multidrug-Resistant MCF-7 Cells: An Identity Crisis?
نویسندگان
چکیده
منابع مشابه
Elevated level of nuclear protein kinase C in multidrug-resistant MCF-7 human breast carcinoma cells.
Previous studies have demonstrated elevated levels of protein kinase C (PKC) activity in multidrug-resistant human breast carcinoma MCF-7/ADR cells compared to control drug-sensitive MCF-7/WT cells (R.L. Fine, J. Patel, and B.A. Chabner, Proc. Natl. Acad. Sci. USA, 85:582-586, 1988). In our present studies, immunohistochemical localization analysis using a polyclonal PKC antibody recognizing th...
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Multidrug resistance (MDR) to chemotherapeutic agents is a major obstacle to successful treatment in breast cancer patients. The aims of this study were to investigate whether miR-137 was involved in the regulation of MDR, and to explore the mechanism of miR-137 on the sensitivity of MCF-7/ADM cells. miR-137 was downregulated in MCF-7/ADM cells, and its expression was found to inversely correla...
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ژورنال
عنوان ژورنال: CancerSpectrum Knowledge Environment
سال: 2002
ISSN: 1460-2105
DOI: 10.1093/jnci/94.21.1654